Environmental Toxicology and Health

Biography

Dr. Asit K. Chakraborti had M. Sc. degree in Organic Chemistry from the University of Burdwan, West Bengal, India in 1977 being placed first in the first class. He received Ph.D. degree in Synthetic Organic Chemistry from IACS, Kolkata, India in 1985. He had post-doctoral research training in USA in the department of Chemistry, Clemson University, South Carolina, during 1985-1987 and in Medicinal Chemistry in Purdue University, Indiana, USA during 1987-1989. He joined the University of Burdwan as a faculty in the department of Chemistry and served during 1990-1994. He joined the department of Medicinal Chemistry, NIPER, S. A. S.Nagar, Punjab, India as Assistant Professor in 1994 and was elevated to the position of Assoc. Professor in 1999 and to Professor and Head in 2001. He has guided 34 Ph. D. and 114 Masters students. He has published 163 research papers (with 7322 citation with h index of 51) and filed 42 patents.

Research Interest

To promote interdisciplinary research and teaching culture. Medicinal Chemistry: Target-based design and syntheses of new chemical entities for various therapeutic areas Tropical communicable and neglected diseases: (a) Tuberculosis: inhibitors of FtsZ protein assembly, His G, isocitrate lyase (ICL), and malate synthase (ML); (b) Leishmaniasis: trypanothiane reductase (TR), ribose-5-phosphate, and HDAC inhibitors. Non-communicable diseases: (a) Diabetes: PTP1B, GOAT inhibitors; (b) Inflammation: selective COX-2, COX-LOX dual inhibitors for rheumatoid arthritis and their implication in other disease control such as cancer and CNS disorder; and PDE-IVB inhibitors for asthma and COPD. Organic Chemistry: Catalysis: Development of transition-metal catalysed and organocatalytic C-H activation reactions; noble/non-noble metal derived nanocatalysts; and hetero-bimetallic hybrid nanocatalysts for generation of new bio-active carbogens and late functionalisation of bioactive scaffolds. Green/Sustainable Chemistry: Development of heterogeneous/solid-supported catalysts for organic reactions; microwave-assisted organic reactions; Use of innocuous reaction media- water, ionic liquids, and fluorous solvents; Molecular level understanding of the role of water in promoting organic reactions; Non-solvent (organo-catalytic) uses of ionic liquids and delineating their role and the origin of catalysis for predictive catalyst modeling. Combinatorial Chemistry: Development of methodologies for solid/solution phase synthesis of small molecular libraries; Strategies for new linkers and analytical protocols. Natural Products/Drug Synthesis: Greener synthetic routes to bio-active natural products, cardiovascular drugs, and other biologically active molecules; All-water and protecting group-free synthetic strategies.